调节性T细胞与非酒精性脂肪性肝病

Regulatory T cell and nonalcoholic fatty liver disease

非酒精性脂肪性肝病已成为全世界常见的慢性肝病。近年来研究表明,免疫调节紊乱在NAFLD发病中具有重要作用,特别是适应性免疫的调节性T细胞(Treg)在NAFLD发病机制中的作用不容忽视。本文对NAFLD疾病过程中Treg的变化、影响Treg分化发育的因素,以及目前报道与调节Treg相关的治疗等进行综述。

Non-alcoholic fatty liver disease has become the most common chronic liver disease in the world.Studies recently have shown that immunoregulatory disorders,especially adaptive immune regulatory T cells (Treg),play a key role in the pathogenesis of NAFLD,which can not be ignored.This article reviews the changes in Treg during NAFLD disease,the factors influencing the differentiation and development of Tregs,and the current reports on the treatment associated with regulatory Tregs.