α疱疹病毒gE和gI蛋白的多样化功能

Diverse Functions of the gE and gI Proteins of Alphaherpesviruses

疱疹病毒为双股线性DNA病毒,是引起人与动物疾病的一类重要病原,成熟的病毒粒子由核心、衣壳、间层及囊膜组成。近年来,对以单纯疱疹病毒(Herpes simplex virus,HSV)及伪狂犬病病毒(Pseudorabies virus,PRV)等为代表的α疱疹病毒在病毒复制和增殖、毒力、神经系统侵染机制以及对机体免疫应答影响等方面的研究取得了显著进展,在病毒基因组编码的多种蛋白中,gE和gI蛋白在上述各方面均发挥关键作用。本文就gE和gI蛋白在α疱疹病毒中的多样化功能的最新研究成果进行了总结,并指出其未来研究趋势。

Alphaherpesviruses are double-stranded DNA viruses,and are important pathogens causing different diseases in humans and animals.In recent years,considerable progress has been made in finding the determinants of viral virulence and the mechanisms underlying neuroinvasive viral infections and the host’s immune responses to the herpes simplex virus and pseudorabies virus(which are alphaherpesviruses).Moreover,the gE and gI proteins of alphaherpesvirus have diverse roles in various signaling pathways.In this review,we summarize the diverse functions of the gE and gI proteins in the lifecycle of alphaherpesvirus,and discuss future research trends.