健康体检人群中血脂与亚临床动脉硬化检测指标之间的关系

The relationship between blood lipid level and subclinical arteriosclerosis index among people who underwent health examination

目的探讨临床常见的8项血脂检查水平是否是影响亚临床动脉硬化的因素。方法对257例在安徽省立医院健康管理中心的体检者进行横断面的研究,给予问卷调查,采集年龄、性别、身高、体重、BMI、血压等指标,使用全自动生化分析仪测定总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、极低密度脂蛋白(VLDL)、高密度脂蛋白(HDL)、载脂蛋白A(Apo A)、载脂蛋白B(Apo B)、脂蛋白a(Lpa)8项血脂指标,并使用动脉硬化仪检测亚临床动脉硬化指标臂踝脉搏波传导速度(baPWV)和踝臂指数(ABI)。对检测结果进行t检验并建立线性回归方程。结果体检者根据动脉硬化检测仪的结论分为对照组和硬化组。硬化组的收缩压、舒张压均高于对照组(均P<0.05),2组的baPWV及ABI差异有统计学意义(均P<0.05)。2组之间血脂比较,其中TC、TG、LDL、VLDL、Apo B差异有统计学意义(均P<0.05),而HDL、Apo A、Lpa差异无统计学意义(均P>0.05)。建立baPWV线性回归方程:Y1=12.19X1+23.07X2+7.67X3-156.13(Y1代表baPWV值,X1代表年龄,X2代表甘油三酯,X3代表收缩压,R=0.740,R2=0.548,P<0.05)。ABI线性回归方程:Y2=0.732+0.002X1+0.002X2(Y2代表ABI值,X1代表年龄,X2代表身高,R=0.358,R2=0.128,F=18.284,P<0.01)。结论血脂八项中TC、TG、VLDL、Apo B是亚临床动脉硬化的影响因子,其中TG与亚临床动脉硬化之间有线性关系。

Objective To explore whether the blood lipid level is associated with subclinical arteriosclerosis index. Methods A total of 257 subjects from the Health Management Center of the First Affiliated Hospital of USTC Anhui Provincial Hospital were investigated. Their name, age, gender, height, weight, BMI, and blood pressure were collected via questionnaire. The total cholesterol, triglyceride, low density lipoprotein cholesterol, very small low-density lipoprotein cholesterol, high density lipoprotein cholesterol, apolipoprotein A, apolipoprotein B, and lipoprotein a were tested by automatic biochemical analyzer, and the baPWV and ABI were used to evaluate arterial stiffness. The results were calculated by t test and linear regression. Results All the subjects were divided into two groups, including subclinical arteriosclerosis group and control group. Study showed that systolic pressure and diastolic pressure in the subclinical arteriosclerosis group than those in the control group(P<0.05). Both baPWV and ABI showed significant difference between the two groups(P<0.05). To compare serum lipid level, TC, TG, LDL, VLDL and Apo B were statistically significant(P<0.05), while HDL, Apo A and Lpa between two groups indicated no difference(P>0.05). The equation of baPWV is Y1=12.19 X1+23.07 X2+7.67 X3-156.13(Y1:baPWV;X1:age;X2:TG;X3:SBP;R=0.740, R2=0.548, P<0.05). The equation of ABI is Y2=0.732+0.002 X1+0.002 X2(Y2:ABI;X1 :age;X2:height;R=0.358, R2=0.128, F=18.284, P<0.01). Conclusion TC, TG, VLDL and ApoB were influence factors of subclinical arteriosclerosis, while TG is an independent risk factor in the regression equation.