益肾活血中药联合电针穴位刺激治疗脑梗死后记忆功能障碍的疗效

Efficacy of Yishen Huoxue decoction combined with electroacupuncture on memory dysfunction after cerebral infarction

目的评价益肾活血中药联合电针穴位刺激治疗脑梗死后记忆功能障碍的疗效。方法将温州市龙湾第一人民医院2015年12月-2017年12月收治的84例脑梗死后记忆功能障碍患者采用随机数字表法分为对照组42例(给予脑梗死西医常规治疗)、联合治疗组42例(在对照组治疗的基础上加用益肾活血方联合电针灸)。比较2组治疗后中医证候积分,记忆量表评分、记忆商,血清MDA、SOD水平,大脑动脉的平均血流速度,临床疗效及不良反应等。结果 2组治疗后各项中医证候评分均较治疗前下降(均P<0.05),联合组治疗后的下降程度较对照组更明显(均P<0.05)。对照组治疗后记图、再认、再生得分、总分及记忆商较治疗前升高,差异有统计学意义(均P<0.05);联合组治疗后记图、再认、再生、计数1~100、背数、总分及记忆商较治疗前升高,差异有统计学意义(均P<0.05);且联合组在记图、再认、再生、计数1~100、背数、总分及记忆商的升高程度较对照组更明显,差异有统计学意义(均P<0.05)。2组治疗后MDA、SOD水平较同组治疗前比较差异有统计学意义(均P<0.05),联合组治疗后的变化程度较对照组更明显(均P<0.05)。2组治疗后MCA、ACA、PCA和BA的血流速度较治疗前均明显加快,联合组明显优于对照组(均P<0.05)。联合组治疗后临床有效率(92.86%)明显高于对照组(71.43%)。结论益肾活血中药联合电针穴位刺激治疗脑梗死后记忆功能障碍安全、有效。

Objective To investigate the efficacy of Yishen Huoxue decoction combined with electroacupuncture on memory dysfunction after cerebral infarction. Methods According to the digital table method, 84 patients with memory dysfunction after cerebral infarction were divided into control group(42 cases) treated with routine western medicine and donepezil, and combined group(42 cases) treated with Yishen Huoxue Decoction combined with electro-acupuncture on the basis of control group. The differences between TCM syndrome scores, memory scale score, memory quotient, serum MDA, SOD level, mean blood flow velocity of cerebral arteries, clinical efficacy and adverse reactions were compared between the two groups. Results The scores of TCM syndromes in the two groups were lower than those before treatment(all P<0.05), and the decrease in the combination group was more obvious than that in the control group(all P<0.05). After treatment, the scores, recognition, regeneration scores, total scores and memory quotient were significantly higher than those before treatment(all P<0.05). After treatment, the combined group was recorded, recognized, regenerated, counted 1-100, Back number, total score and memory quotient were higher than those before treatment, the difference was statistically significant(all P<0.05). In the combined group, the increase in the scores, recognition, regeneration, count 1-100, back number, total score and memory quotient was more significant than those in the control group(all P<0.05). The levels of MDA and SOD in the two groups were significantly different from those before treatment(all P<0.05). The difference in the changes after treatment in the combined group was more significant than that in the control group(all P<0.05). The blood flow velocity of MCA, ACA, PCA and BA in the combined group were significantly faster than those in the control group(all P<0.05). The clinical effective rate(92.86%) in the combined group was significantly better than that in the control group(71.43%). Conclusion Yishen Huoxue decoction combined with electroacupuncture is a safe and effective treatment for memory dysfunction after cerebral infarction.