58例药物性肝功能损害案例的不良反应分析及其对策

Analysis of Adverse Drug Reactions in 58 Patients of Drug-induced Liver Function Impairment and Its Countermeasures

目的:分析药物性肝功能损害案例的不良反应发生特点,为临床预防和治疗肝功能损害提供参考。方法:通过国家药品不良反应监测系统调取医院2016年-2018年间上报的药物致肝功能损害的不良反应报告58例,统计其不良反应患者的性别、年龄和药物类别、不良反应严重程度、不良反应转归等方面的资料,并分析其药物性肝功能损害案例的不良反应发生特点。结果:3年期间上报的药品不良反应报告197例,涉及药物性肝功能损害患者58例占29.44%;而58例药物性肝功能损害患者中症状严重的49例占84.48%;涉及12大类药物,以抗结核药物和抗菌药物的发生率为最高,分别为36.11%和16.67%;经相关治疗58例患者均被治愈。结论:上报的药品不良反应报告中涉及药物性肝功能损害的发生率较高,临床应引起高度重视,采取适当措施预防药物性肝功能损害的发生、发展,并及时给予有效治疗。

Objective:To analyze the characteristics of adverse drug reactions in cases of drug-induced liver function impairment,and to provides a reference for clinical prevention and treatment of liver function damage.Methods:58 cases of adverse reactions caused by drugs to liver function damage were reported from 2016 to 2018 by the National Adverse Drug Reaction Monitoring System.The gender,age,type of drugs,severity of adverse reactions and outcome of adverse reactions of the patients with adverse reactions were counted,and the occurrence characteristics of adverse reactions in drug-induced liver function impairment cases were analyzed.Results:During the 3-year period,197 cases of adverse drug reactions were reported,including 58 cases of drug-induced liver function impairment(accounting for29.44%).Of the 58 patients with drug-induced liver function impairment,49 had severe symptoms(accounting for84.48%).The incidence of antituberculosis drugs and antibacterial drugs was the highest,36.11%and 16.67%respectively.All the 58 patients were cured.Conclusion:The incidence of drug-induced liver function impairment is relatively high in the reported adverse drug reaction reports,which should be attached great importance to clinically.Appropriate measures should be taken to prevent the occurrence and development of drug-induced liver function impairment,and effective treatment should be given in time.