血清降钙素原、血小板、C反应蛋白、乳酸的检测对脓毒血症病人预后判断的价值

THE PROGNOSTIC VALUE OF SERUM PROCALCITONIN,PLATELET,C-REACTIVE PROTEIN AND LACTIC ACID IN PATIENTS WITH SEPSIS

目的:探讨脓毒血症病人血清降钙素原(PCT)、血小板(PLT)计数、C反应蛋白(CRP)、乳酸(LAC)的水平对判断病人病情严重程度及预后状况的应用价值。方法:选择2016-01~2018-06期间在我院诊治的90例脓毒血症病人(脓毒血症组),并选择同期在我院治疗的非脓毒血症病人90例(对照组),检测2组病人早期血清PCT、PLT计数、CRP及LAC的水平,并记录脓毒血症组病人30d内的预后情况。结果:脓毒血症病人的血清PCT、CRP、LAC水平均明显高于对照组(P<0.05);脓毒血症的血清PLT计数明显低于对照组(P<0.05);脓毒血症休克病人血清PCT、CRP、LAC水平均明显高于其他两组病人(P<0.05);血清PLT计数明显低于两组病人(P<0.05);脓毒血症病人入院后死亡28例,病死率31.11%,死亡组病人的血清PCT、CRP、LAC水平均明显高于存活组病人(P<0.05);死亡组病人的PLT计数明显低于存活组病人(P<0.05)。结论:联合检测血清PCT、PLT计数、CRP及LAC水平对判断脓毒血症病人病情严重程度及预后状况具有较高的临床价值。

Objective:To investigate the value of serum procalcitonin,platelet,C-reactive protein and lactic acid in judging the severity and prognosis of sepsis. Methods:90 sepsis patients(sepsis group)and 90 non-sepsis patients(control group)were selected from January 2016 to June 2018.The levels of PCT,PLT,CRP and LAC in serum of the two groups were detected in the early stage,and the prognosis of the sepsis group within 30 days was recorded. Results:The serum levels of PCT,CRP and LAC in sepsis patients were significantly higher than those in control group( P < 0.05 ),the serum PLT count in sepsis patients was significantly lower than that in control group( P < 0.05 ),and the serum levels of PCT,CRP and LAC in sepsis shock patients were significantly higher than those in other two groups( P < 0.05 ).The mortality rate was 31.11 %.The levels of PCT,CRP and LAC in the death group were significantly higher than those in the survival group( P < 0.05 ).The P LT count in the death group was significantly lower than that in the survival group( P < 0.05 ). Conclusion:Combined detection of serum PCT,PLT count,CRP and LAC levels has a high clinical value in judging the severity of sepsis and prognosis.