甲羟孕酮联合宫腔镜手术治疗子宫内膜息肉对患者康复及预后的影响

Effect of medroxyprogesterone combined with hysteroscopy in the treatment of endometrial polyps on rehabilitation and prognosis of patients

目的探讨甲羟孕酮联合宫腔镜手术治疗子宫内膜息肉对患者康复及预后的影响。方法选取2016年8月至2017年8月于我院就诊的100例子宫内膜息肉患者为研究对象,按照抽签的方法将其分为对照组与观察组,各50例。对照组给予宫腔镜手术治疗,观察组给予甲羟孕酮联合宫腔镜手术治疗。比较两组的治疗效果。结果观察组经期延长、月经量增加、经期腹痛、阴道不规则出血等改善有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗后,两组子宫内膜厚度均减小,且观察组小于对照组,差异有统计学意义(P<0.05)。治疗后,观察组E2、FSH、LH水平显著低于对照组,差异有统计学意义(P<0.05)。观察组术后1年妊娠率高于对照组,复发率低于对照组,差异有统计学意义(P<0.05)。结论甲羟孕酮联合宫腔镜手术应用于子宫内膜息肉中具有较高的临床价值,能够在缓解临床症状的同时降低复发率,值得应用及推广。

Objective To investigate the effect of medroxyprogesterone combined with hysteroscopy in the treatment of endometrial polyps on rehabilitation and prognosis of patients. Methods From August 2016 to August 2017, 100 patients with endometrial polyps treated in our hospital were selected as the study objects and divided into control group and observation group according to the method of drawing lots, with 50 cases in each group. The control group was treated with hysteroscopy, while the observation group was treated with medroxyprogesterone combined with hysteroscopy. The therapeutic effects of the two groups were compared. Results The effective rates of prolonged menstruation, increased menstrual volume, menstrual abdominal pain and irregular vaginal bleeding improvement in the observation group were significantly higher than those in the control group, and the differences were statistically significant(P <0.05). After treatment, the endometrial thickness of the two groups decreased, and that in the observation group was smaller than the control group, the difference was statistically significant(P<0.05). After treatment, the levels of E2, FSH and LH in the observation group were significantly lower than those in the control group, and the differences were statistically significant(P <0.05). The pregnancy rate in the observation group was higher than that in the control group at one year after operation, and the recurrence rate was lower than that in the control group, and the differences were statistically significant(P<0.05). Conclusion Medroxyprogesterone combined with hysteroscopic surgery has a high clinical value in the application of endometrial polyps. It can relieve the clinical symptoms and reduce the recurrence rate, which is worthy of application and promotion.