外膜滋养血管在动脉粥样硬化易损斑块中的研究现状

Research advance of outer membrane vasa vasorum in atherosclerotic vulnerable plaque

随着对动脉粥样硬化(As)的深入研究,促进易损斑块的稳定性成为As新的治疗理念。在As“由内而外”学说中血管内膜的病理改变成为始动因素,然而近年研究表明外膜新生滋养血管(VV)在As“由外向内”发病机制中起到关键作用,总之,对于As的治疗已从保护血管内膜转变为调节外膜VV。

With the in-depth study of atherosclerosis (As),promoting the stability of vulnerable plaque has become a new therapeutic concept for As.In the “inside-out” theory of As,the pathological changes of the intima are the initiating factors.However,recent studies have shown that the vasa vasorum (VV) plays a key role in the pathogenesis of As from the outside to the inside.In summary,treatment of As has changed from protecting the intima to regulating the outer membrane VV.