环境内分泌干扰物与乳腺癌的关系

Roles of common environmental endocrine disrupters in development and progress of breast cancer:a review of recent studies

环境内分泌干扰物广泛存在于食品包装材料、化妆品等及环境介质中。该文对3种常见环境内分泌干扰物(双酚A、邻苯二甲酸酯、多氯联苯)与乳腺癌关系的相关研究进行综述,包括其在环境中的分布、摄入途径、暴露剂量、在人体内的分布、对乳腺癌发生发展影响的流行病学研究,并列举诱发乳腺癌的相关机制,如基因和表观遗传层面的调节机制、通过雌激素受体(ER)介导的拟雌激素效应、诱导产生活性氧、诱导非ER介导的信号通路激活以及微环境调节等,并对未来相关毒理学和分子机制研究及流行病学研究方向进行展望。

Endocrine disrupters (EDs) are widely found in food-packaging materials, cosmetics, etc. and environmental media. This paper summarized the studies of several synthetic xenoestrogens (bisphenolA, phthalates, polychlorinated biphenyls) and their roles in breast cancer tumorigenesis, including the distribution in the environment and in the human body, and the routes and levels of exposure. Epidemiological studies examining the relationship between exposure of EDs and breast cancer were also included. Furthermore, the studies on the mechanisms of action of BPA were also summarized, such as genetic and epigenetic regulation,ER -mediated xenoestrogenic activity,induction of ROS,activation of ER -independent signaling pathways, and regulation via micro-environment.Understanding the effects and mechanisms of EDs involved in breast cancer development would help to reduce EDs exposure and provide further information for future research.