金黄色葡萄球菌耐药基因及新型抗菌药物的研究进展

Research on drug-resistant genes and new anti-bacterial agents against Staphylococcus aureus

金黄色葡萄球菌(Staphylococcus aureus,S.aureus),简称金葡菌,是一种临床常见致病菌,可引起皮肤化脓性感染、肺炎、心包炎、败血症及脓毒血症等多种疾病。目前临床上金黄色葡萄球菌的多重耐药情况已十分严峻,特别是耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus,MRSA)的出现,已成为临床抗感染治疗的棘手难题,严重危害人类健康。本文主要介绍金黄色葡萄球菌基因水平的耐药性、新型抗菌药物的研发及临床治疗金黄色葡萄球菌感染三方面的进展,为金黄色葡萄球菌的耐药性研究及耐药菌株的临床有效治疗提供科学依据。

Staphylococcus aureus is a kind of common clinical pathogen,which can cause skin purulent infection,pneumonia,pericarditis,sepsis and other diseases.The current situation of clinical multi-drug resistance of Staphylococcus aureus is very serious, threatening human life and health,especially methicillin-resistant Staphylococcus aureus(MRSA)which has become a thorny problem in clinical anti-infection.We mainly introduce the drug resistance of Staphylococcus aureus on genetic level,new antibacterial drugs and clinical treatment of Staphylococcus aureus infections,in order to provide scientific basis for the study on drug resistance of Staphylococcus aureus and for effective treatment of resistant strain-associated infections.