5%复方利多卡因乳膏缓解眼睑痉挛患者注射A型肉毒毒素相关疼痛的效果

Efficiency of 5% compand lidocaine cream on alleviating pain from botulinum toxin A injections for blepharospasm

目的评价5%复方利多卡因乳膏缓解眼睑痉挛患者注射A型肉毒毒素相关疼痛的效果。设计病例对照研究。研究对象采取便利抽样法,选取24例2018年8-12月在北京同仁医院因眼睑痉挛接受A型肉毒毒素注射治疗,且在既往未给予疼痛干预情况下,视觉模拟评分法(visual analogue scale,VAS)疼痛评分≥8分的患者。方法采用数字随机法随机确定观察眼的眼别,观察眼眼睑注射部位在注射前给予5%复方利多卡因乳膏涂抹30分钟,对侧眼眼睑注射部位未予干预作为对照。注射后立即应用VAS对患者进行疼痛评分,2周后随访,记录其他不良反应。主要指标 VAS疼痛评分、不良反应。结果 24例观察眼的VAS疼痛评分为6.73±1.25,对照眼为8.68±0.42(P=0.000),随访期间未观察到明显不良反应。结论 5%利多卡因乳膏可以安全、有效地缓解眼睑痉挛患者接受A型肉毒毒素注射时的相关疼痛,可临床推广应用。

Objective To evaluate the efficiency of 5% compand lidocaine cream on alleviating pain from botulinum toxin A (BTX-A) injections for bilateral blepharospasm. Design Case-controlled study. Participants 24 patients who were treated with BTX-A injections for bilateral blepharospasm in Beijing Tongren Hospital were selected from August 2018 to December 2018 and whose previous VAS pain score was not less than 8 without pain intervention. Methods BTX-A injections were given in both eyes of the patients. 5% compand lidocaine cream was applied for 30 minute prior to BTX-A injections on one side (right-left design by random number table, observed side), whereas the other side received BTX-A injections only (control side). Patients completed VAS pain score immediately after injections and were followed up 2 weeks later to observe the side-effects. Main Outcome Measures VAS pain score, side effects. Results The average pain score of all 24 patients was 6.73±1.25 on the observed side and 8.68±0.42 on the control side (P=0.000). All 24 patients experienced no significant side effects during the follow-up period. Conclusion 5% compand lidocaine cream represents a safe and effective means to alleviate pain from botulinum toxin A injections for bilateral blepharospasm patients.