Endocan与糖尿病周围神经病变的相关性研究

The correlation between endocan and diabetic peripheral neuropathy

目的探讨血清endocan水平与糖尿病周围神经病变(DPN)的相关性。方法选取2015年4月至2015年11月在甘肃省人民医院内分泌科住院的2型糖尿病(T2DM)患者67例,分为DPN组(25例)和单纯T2DM组(42例),同期性别、年龄匹配的28名健康志愿者作为正常对照组(NC组)。采用ELISA法测定血清endocan水平,同时测定其他代谢指标。应用Pearson相关分析、logistic回归及受试者工作特征(ROC)曲线分析endocan与DPN的相关性。结果与NC组相比,DPN组及单纯T2DM组血清endocan水平明显升高(F=24.26,P<0.05),且与单纯T2DM组相比,DPN组血清endocan水平显著升高(t=5.668,P<0.05)。Endocan与病程、年龄呈正相关(r=0.438、0.394,P均<0.05)。Endocan、吸烟、年龄是DPN的危险因素(OR=1.692、9.880、1.093,95%CI:1.279~2.237、2.039~47.878、1.024~1.168,P均<0.05)。ROC分析结果显示,endocan曲线下面积为0.824(95%CI:0.727~0.921,P=0.000)。结论Endocan与DPN相关,可能是DPN的一种新的生物学标志物。

Objective To investigate the correlation between serum endocan level and risk of diabetic peripheral neuropathy(DPN). Methods A total of 67 patients with type 2 diabetes mellitus (T2DM) were recruited from the Department of Endocrinology in Gansu Provincial Hospital From April 2015 to November 2015. All patients were divided into DPN group (n=25) and simple T2DM group (n=42). Meanwhile, gender and age matched healthy subjects were included as the normal control group(NC group, n=28). Serum endocan was measured by ELISA, and other metabolic parameters were also tested. Pearson correlation analysis, logistic regression analysis and area of receiver operator characteristic (ROC) curve analysis were used to analyze the correlation between endocan level and DPN risk. Results Compared with NC group, the serum level of endocan was significantly increased in simple T2DM group and DPN group(F=24.26, P<0.05). In addition, compared with simple T2DM group, the serum level of endocan in DPN group was markedly higher (t=5.668, P<0.05). Endocan was positively correlated with the course of disease and age(r=0.438, 0.394, all P<0.05). Endocan level, smoking and age were the independent risk factors for DPN(OR=1.692, 9.880, 1.093, 95% CI: 1.279-2.237, 2.039-47.878, 1.024-1.168, all P<0.05). The results of the ROC analysis revealed that the area under ROC curve was 0.824(95% CI: 0.727-0.921, P=0.000). Conclusion Serum level of endocan is related to DPN, and it may be used as a novel biomarker for DPN.