厚朴麻黄汤联合西药治疗慢性支气管炎随机平行对照研究

Randomized Parallel Controlled Study on Houpu Mahuang Decoction(厚朴麻黄汤) combined with Western Medicine in the Treatment of Chronic Bronchitis

[目的]观察厚朴麻黄汤联合西药治疗慢性支气管炎疗效。[方法]使用随机平行对照方法,将80例住院患者按病志号抽签随机分为两组。对照组40例左氧氟沙星200mL,1次/d,静滴;氨茶碱0.25g+生理盐水250mL,1次/d。治疗组40例厚朴麻黄汤(厚朴、杏仁、石膏~生各15g,麻黄12g,甘草、半夏、白芍、紫菀、小麦各10g,白前、细辛各5g,五味子3g),水煎300mL,早晚分服,1剂/d。痰多可加砂仁、苏子各10g;痰寒去石膏~生,加姜~干8g,桂枝6g;脾虚加党参10g,白术8g;咳嗽严重加~川贝母、枇杷叶各10g;气急加白芥子、莱菔子各10g;西药治疗同对照组。连续治疗14d为1疗程。观测临床表现、咳嗽消失时间、喘息消失时间、水肿消失时间、住院时间、不良反应(恶心呕吐、头晕头痛、腹痛腹泻)。治疗1疗程(14d),判定疗效。[结果]治疗组痊愈23例,显效10例,有效5例,无效2例,总有效率95.00%;对照组痊愈16例,显效9例,有效17例,无效8例,总有效率80.00%;治疗组疗效优于对照组(P<0.05)。咳嗽消失时间、喘息消失时间、水肿消失时间、住院时间治疗组短于对照组(P<0.01)。不良反应无显著差异(P>0.05)。[结论]厚朴麻黄汤联合西药治疗慢性支气管炎,疗效满意,无严重不良反应,值得推广。

[Objective] To observe the curative effect of Houpu Mahuang decoction combined with western medicine on chronic bronchitis.[Method] 80 inpatients were randomly divided into two groups by drawing lots according to the disease sign by random parallel control method. Control group 40 cases of levofloxacin,200 mL, once a day, intravenous drip;aminophylline, 0.25 g + saline 250 mL, once a day. In the treatment group, 40 cases of Houpu Mahuang decoction(Houpo, Xingren, Xingren, Shengshigao each 15 g, Mahuang12 g, Gancao, Baishao, Ziwan, Xiaomai each 10 g, Baiqian, Xixin each 5 g, Wuweizi 3 g) were decocted with water for 300 mL, and taken separately in the morning and evening, one dose per day. Phlegm can be added10 g of Sharen and Suzi, phlegm cold can be removed from Shengshigao, add Ganjiang 8 g, Guzhi 6 g, spleen deficiency plus Dangshen 10 g, Baizhu 8 g, cough was severe with Chuanbeimu, Pipaye each 10 g with batch leaves, white mustard Baijiezi Laifuzi each 10 g, western medicine treatment is the same as the control group.Continuous treatment for 14 days is a course of treatment. Clinical manifestations, cough disappearance time,wheezing disappearance time, edema disappearance time, hospitalization time, adverse reactions(nausea and vomiting, dizziness and headache, abdominal pain and diarrhea) were observed. One course of treatment(14 days) was used to determine the curative effect.[Result] In the treatment group, 23 cases were cured, 10 cases were markedly effective, 5 cases were effective and 2 cases were ineffective, the total effective rate was 95.00%. In the control group, 16 cases were cured, 9 cases were markedly effective, 17 cases were effective and 8 cases were ineffective, the total effective rate was 80.00%. The curative effect of the treatment group was better than that of the control group(P<0.05). The cough disappearance time, wheezing disappearance time, edema disappearance time and hospitalization time in the treatment group were shorter than those in the control group(P<0.01). There was no significant difference in adverse reactions(P>0.05).[Conclusion]Houpu Mahuang decoction combined with western medicine has satisfactory curative effect on chronic bronchitis and no serious adverse reactions. It is worth popularizing.