摘要
目的优选活血散瘀泡腾片的防潮辅料。方法以吸湿率为指标,乳糖、糊精、麦芽糊精、可溶性淀粉为备选辅料,采用D-最优混料设计优选活血散瘀泡腾片的最佳防潮辅料及其配比。结果活血散瘀泡腾片最佳防潮辅料组合为乳糖-可溶性淀粉(7∶3),物料168 h吸湿率为5.8%。结论防潮辅料可有效控制中药固体制剂物料吸湿率,适宜于医疗机构中药固体制剂的研发生产。
Objective To optimize the moisture-proof excipients of Huoxue Sanyu effervescent tablets.Methods Taking moisture rate as the index, lactose, dextrin, maltodextrin and soluble starch as the alternative excipients, the D-optimal mixture design is used to optimize the best moisture-proof excipients and the proportion.Results The best moisture-proof excipients of Huoxue Sanyu effervescent tablets is lactose-soluble starch(7︰3), and the 168 h moisture rate of material is 5.8 %. Conclusion The moisture-proof excipients can effectively control the moisture rate of TCM solid preparation and is suitable for the research and production of TCM solid preparation in medical institution.
作者
彭伟
涂禾
胡恒
祝贺
吴明权
周许
刘李梅
PENG Wei;TU He;HU Heng;ZHU He;WU Ming-quan;ZHOU Xu;LIU Li-mei(Sichuan Provincial Orthopedic Hospital,Chengdu 610041,China)
出处
《现代中药研究与实践》
CAS
2019年第3期54-56,共3页
Research and Practice on Chinese Medicines
基金
四川省骨科医院院内课题(2015-23)
关键词
活血散瘀泡腾片
防潮辅料
D-最优混料设计
吸湿率
Huoxue Sanyu effervescent tablets
moisture-proof excipients
D-optimal mixture design
moisture rate