运动训练对抗肿瘤治疗患者癌因性疲乏及生命质量影响的系统评价与Meta分析

Effects of excise traning on cancer-related fatigue in patients undergoing anticancer treatment: a Meta-analysis of randomized controlled trails

目的系统评价运动训练对缓解抗肿瘤治疗患者癌因性疲乏,提高生命质量的效果。方法严格界定纳入排除标准,计算机检索中英文数据库中关于运动训练对抗肿瘤治疗患者进行干预的随机对照研究,由2名研究者对文献质量进行严格评价和资料提取,对符合质量标准的随机对照研究进行Meta分析。结果共纳入随机对照试验9篇,其中英文7篇,中文2篇。有氧运动可提高患者生命质量(SMD=1.17,P=0.002),缓解其癌因性疲乏的症状(SMD=-1.14,P=0.000 2),并在干预后3~4周内同样有一定效应(P < 0.05);抗阻力训练或抗阻力运动与有氧运动结合并不能缓解患者癌因性疲乏症状(SMD=-0.06,P=0.85),但能提高其生命质量(SMD=0.39,P=0.002)。结论抗肿瘤治疗患者应在专业人员的指导下进行有氧运动,以缓解自身癌因性疲乏症状,提高其生命质量。

Objective To investigate the effectiveness of excise training on cancer-related fatigue (CRF) and quality of life (QOL) in patients undergoing anticancer treatment. Methods Eight databases (PubMed, Medline, Cochran Library, EMBASE, and four Chinese database) were searched to identify randomized controlled trials (RCTs) that evaluated the effects of excise training on CRF and QOL. The quality of literature was strictly evaluated and data extracted by 2 researchers. Meta-analysis was performed on randomized controlled trials that met the quality criteria. Results Nine RCTs involving 847 patients were included. Pooled results suggested that aerobic exercise can improve the QOL (SMD=1.17, P=0.002), alleviate the symptoms of CRF (SMD=-1.14, P=0.000 2), and also have a certain effect within 3-4 weeks after intervention (P < 0.05);resistance training or anti resistance exercise combined with aerobic exercise can not alleviate the patients′ cancer induced fatigue symptoms (SMD=-0.06, P=0.85), but it can improve the quality of life (SMD=0.39, P=0.002). Conclusion Patients with anticancer therapy should undergo aerobic exercise under the guidance of professional personnel to alleviate symptoms of cancer-related fatigue and improve their quality of life.