脑胶质瘤患者血清IGFBP2、miR-29c水平变化及其临床意义

Changes of Serum Levels of IGFBP2 and miR-29c in Patients with Glioma and their Clinical Significance

【目的】探讨脑胶质瘤患者血清类胰岛素样生长因子结合蛋白2(IGFBP2)、微小RNA29c(miR-29c)水平变化及其临床意义。【方法】选取2016年1月至2017年12月本院收治的80例脑胶质瘤患者(观察组),选取同期于本院健康体检80例志愿者作为对照组。检测两组血清IGFBP2、miR-29c水平,并分析不同肿瘤直径、病理学类型、WHO分级、肿瘤位置的患者血清IGFBP2、miR-29c水平。【结果】观察组患者血清IGFBP2水平显著高于对照组,血清miR-29c水平显著低于对照组,差异均具有统计学意义(P<0.05)。WHO分级Ⅲ级患者血清IGFBP2水平显著高于Ⅰ级、Ⅱ级患者,而血清miR-29c水平显著低于Ⅰ级、Ⅱ级,其差异均具有统计学意义(P<0.05);不同病理学类型、病灶直径、肿瘤部位的患者血清IGFBP2、miR-29c水平比较,差异无统计学意义(P>0.05)。【结论】脑胶质瘤患者血清IGFBP2水平升高、miR-29c表达水平降低,并且与肿瘤分级具有相关性。

【Objective】To investigate the changes of serum insulin-like growth factor binding protein 2 (IGFBP2) and microRNA-29c (miR-29c) levels in patients with glioma and their clinical significance.【Methods】Eighty patients with glioma diagnosed in our hospital from January 2016 to December 2017 (case group), 80 healthy subjects with age, gender and case group were selected as the control group, and the serum of the two groups were tested. IGFBP2 and miR-29c levels were analyzed by stratification according to tumor diameter, pathological type, WHO classification, and tumor location.【Results】The level of serum IGFBP2 in the observation group was significantly higher than that in the control group, and the level of serum microRNA-29c was significantly lower than that in the control group, with statistical significance (P<0.05). The serum levels of IGFBP2 and microRNA-29c in patients with WHO grade Ⅲ were significantly higher than those in patients with WHO grade Ⅰ and Ⅱ, while the serum levels of microRNA-29c were significantly lower than those in patients with WHO grade Ⅰ and Ⅱ(P<0.05);there was no significant difference in serum levels of IGFBP2 and microRNA-29c between patients with different pathological types, lesion diameters and tumor sites (P>0.05).【Conclusion】The level of serum IGFBP2 increases and the expression of microRNA-29c decreases in glioma patients, which is correlated with the grade of glioma.