Cys-C、β2-微球蛋白和RBP在2型糖尿病肾病患者中的表达及意义

Expression and Clinical Significance of Cys-c,β2-microglobulin and RBP in Patients with Type 2 Diabetic Nephropathy

【目的】探讨胱抑素C(Cys-C)、β2-微球蛋白(β2-MG)和视黄醇结合蛋白(RBP)P在2型糖尿病肾病患者中的表达及临床意义。【方法】81例2型糖尿病肾病患者,根据其尿白蛋白排泄率(UAER)水平不同分为A组(30例)、B组(24例)、C组(27例),另选取同期进行健康体检的26例健康者为对照组。比较四组对象Cys-C、β2-MG和RBP表达水平,用ROC曲线分析血清Cys-C 、β2-MG和RBP含量在诊断2型糖尿病肾病中的敏感性、特异性等。【结果】对照组的Cys-C 、β2-MG和RBP水平和A组比较差异无显著性(P>0.05),对照组和A组的Cys-C、β2-MG和RBP水平显著低于B组、C组(P<0.05),B组各指标水平显著低于C组(P<0.05)。经ROC曲线分析显示,将健康人群测定值作为比较,Cys-C,β2-MG,RBP在2型糖尿病肾病患者中均有较高的敏感度和特异性。【结论】Cys-C、β2-微球蛋白和RBP在2型糖尿病肾病患者的临床诊断、治疗及病情监测中发挥着重要价值,均有着较高的敏感度和特异性。

【Objective】 To study the expression and clinical significance of Cys-c (cystatin C),β2-MG (β2-microglobulin) and RBP (retinol binding protein) in patients with type 2 diabetic nephropathy.【Methods】Eighty-one patients with type 2 diabetic nephropathy were enrolled in this study. According to urinary albumin excretion rate (UAER), patients were divided into group A (30 cases), group B (24 cases) and group C (27 cases). In the same period, 26 healthy volunteers were enrolled as the control group. The levels of Cys-c,β2-microglobulin and RBP in the four groups of patients were recorded. ROC curve was used to analyze the sensitivity and specificity of serum Cys-c,β2-MG and RBP content in the diagnosis of type 2 diabetic nephropathy .【Results】 The levels of Cys-c,β2-MG and RBP in the control group were not significantly different from those in group A (P>0.05). The levels of Cys-c,β2-MG and RBP in the control group and group A were significantly lower than those in group B and group C (P<0.05). The levels of Cys-c,β2-MG and RBP in group B were significantly lower than those of group C (P<0.05).【Conclusion】 Cys-c,β2-microglobulin and RBP play an important role in the clinical diagnosis, treatment and disease monitoring of patients with type 2 diabetic nephropathy, all of which have high sensitivity and specificity.