幽门螺杆菌感染与非酒精性脂肪性肝病的相关性

Study on Association between Helicobacter Pylori Infection and Nonalcoholic Fatty Liver Disease

【目的】探讨幽门螺杆菌(H.pylori,Hp)感染与非酒精性脂肪性肝病(NAFLD)之间的关系。【方法】选取2013年10月至2017年10月于本院门诊及住院确诊为NAFLD的患者共260例作为观察组。选取同期例数相同的腹部超声肝脏形态正常者作为对照组。所有受试者一般数据完整,均进行14C-尿素呼气试验检测Hp。应用非条件Logistic回归分析Hp感染状态与NAFLD的关系。【结果】观察组Hp感染率为65.4%,明显高于对照组的47.3%(P<0.05);Logistic回归分析显示,Hp感染、BMI、LDL-C与NAFLD密切相关,其中Hp感染与NAFLD呈正相关(OR=3.66)。【结论】 Hp感染可能是NAFLD的独立危险因子。

【Objective】 To explore the relationship between Helicobacter pylori (H.pylori) infection and nonalcoholic fatty liver disease (NAFLD).【Methods】A total of 260 patients with NAFLD diagnosed in our hospital from October 2013 to October 2017 were selected as the observation group. At the same time period, 260 healthy volunteers were selected as the control group. The general data of all subjects were completely recorded and the 14C-urea breath test for H.pylori infection was conducted by 14C-urea breath test. The relationship between H.pylori infection status and NAFLD was analyzed by unconditioneal Logistic regression.【Results】The overall infection rate of H.pylori in the two groups was 56.3%. The detection rate of H.pylori infection in the NAFLD group was 65.4%, which was significantly higher than that in the control group 47.3%(P<0.01). Logistic regression analysis showed that H.pylori infection, Body Mass Index, and Low Density Lipoprotein Cholesterol (LDL-C) were closely related to NAFLD.Among them, H.pylori infection was positively correlated with NAFLD (OR=3.66).【Conclusion】 The H.pylori infection may be an independent risk factor for NAFLD.