颅内动脉瘤中OPN和PINCH蛋白的表达及意义被引量：2

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摘要【目的】探讨骨桥蛋白(OPN)及PINCH 蛋白在颅内动脉瘤中的表达及其意义。【方法】选取本院收治的行开颅动脉瘤加闭术中切取的标本41例,其中破裂动脉瘤17例,未破裂动脉瘤24例,另取正常脑动脉标本10例作对照。应用SP免疫组织化学方法检测OPN和PINCH在动脉瘤及正常脑动脉中的表达。【结果】OPN和PINCH蛋白在对照组脑动脉壁中膜表达微弱,而在动脉瘤壁中膜表达显著增强;动脉瘤组OPN平均光密度值为(0.215±0.064)显著高于对照组的(0.096±0.027);动脉瘤组PINCH平均光密度值为(0.247±0.066)显著高于对照组(0.158±0.024),差异均有统计学意义(P<0.05)。未破裂组OPN平均光密度值为(0.236±0.071)显著高于破裂组(0.184±0.038);未破裂组PINCH平均光密度值为(0.269±0.069)显著高于破裂组(0.217±0.049),差异均有统计学意义(P<0.05)。OPN与PINCH呈正相关(P<0.05);OPN与动脉瘤直径呈正相关(P<0.05)。【结论】颅内动脉瘤中OPN、PINCH高表达,且二者在未破裂动脉瘤中表达水平显著高于破裂动脉瘤,且两组呈显著正相关。

作者彭玉涛李鹏波李涛赵奇煌徐跃峤

机构地区首都医科大学附属北京朝阳医院首都医科大学三博脑科医院首都医科大学宣武医院

出处《医学临床研究》 CAS 2019年第5期951-953,共3页 Journal of Clinical Research

关键词颅内动脉瘤骨桥蛋白质

分类号 R6511.22 [医药卫生—外科学]

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1赵强,王洪,顾平,史彦芳,宋颖,王铭维,朱振龙,孙晓峰.PINCH蛋白在垂体腺瘤中的表达及其意义[J].中国全科医学,2012,15(3):281-284. 被引量：1

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