食管癌组织中前梯度蛋白2和上皮性钙黏蛋白的表达及其临床意义

Expression of AGR2 and E-cadherin in esophageal carcinoma tissues and its clinical significance

目的:探讨前梯度蛋白2(AGR2)和上皮性钙黏蛋白(E-Cad)在食管癌组织中的表达及其临床意义。方法:采用免疫组化染色检测109例食管癌组织和77例癌旁组织中AGR2和E-Cad的表达,比较AGR2、E-Cad与食管癌患者临床病理参数的关系;Kaplan-Meier检验分析不同AGR2、E-Cad表达与食管癌患者总体生存率的关系。结果:AGR2在食管癌组织中的阳性表达率(73. 8%)显著高于癌旁组织的10. 4%(P <0. 05),E-Cad在食管癌组织中的阳性表达率(21. 4%)显著低于癌旁组织的90. 9%(P <0. 05),食管癌组织中AGR2及E-Cad的表达与肿瘤淋巴结转移、TNM分期相关(均P <0. 05)。总体生存率AGR2高表达食管癌患者明显低于低表达患者,E-Cad高表达患者明显高于低表达患者(均P <0. 05);食管癌组织中AGR2的表达与E-Cad表达呈负相关(r=-0. 767,P <0. 05)。结论:食管癌组织中AGR2、E-Cad表达异常;AGR2高表达和E-Cad低表达可能与肿瘤转移、食管癌不良预后相关。

Objective: To explore anterior gradient 2( AGR2) and E-cadherin( E-Cad) expression in esophageal carcinoma tissues and its clinical value for prognosis. Methods: The expression levels of AGR2 and E-Cad in 109 esophageal carcinoma tissues and 77 paracancerous tissues were determined by immunohistochemical staining,and the relationship between the expression of AGR2,E-Cad and the clinicopathological parameters of esophageal cancer patients were compared. The over-all survival rate of the patients was analyzed by Kaplan-Meier method.Results: The expression of AGR2 in esophageal carcinoma tissues( 73. 8%) was significantly higher than that in paracancerous tissues( 10. 4%)( P < 0. 001). The expression of E-Cad in esophageal carcinoma tissues( 21. 4%)was significantly lower than that in paracancerous tissues( 90. 9%)( P < 0. 001). The expression of AGR2 was related to lymph node metastasis and TNM staging( P < 0. 05). The over-all survival rate in the AGR2 higher expression group was markedly lower than that in the lower expression group,and the over-all survival rate in the higher E-Cad expression group was markedly higher than that in the lower expression group( P < 0. 05). There was a negative correlation between AGR2 and E-Cad in the esophageal carcinoma tissues( r =-0. 767,P < 0. 05).Conclusion: Aberrant expression of AGR2 and E-Cad in esophageal cancer tissues,the up-regulated of AGR2 and down-regulated of E-Cad are risk factors for tumor metastasis and poor prognosis.