四种常见贫血患者红细胞寿命的研究

Life span of red blood cells in patients with four common types of anemia

目的:研究自身免疫性溶血性贫血(AIHA)患者的红细胞寿命,并与常见贫血患者的红细胞寿命比较。方法:回顾性分析AIHA、骨髓增生异常综合征(MDS)、重型再生障碍性贫血(SAA)和缺铁性贫血(IDA) 4组共55例患者的临床资料,以同期12例健康志愿者为正常对照组。采用一氧化碳(CO)呼气法测定红细胞寿命,比较4种贫血患者和健康志愿者红细胞寿命并作分析。结果:AIHA患者红细胞寿命为(30.41±31.12)d,比MDS(53.44±32.61)d、SAA(54.53±22.56)d和IDA(58.75±31.29)d患者的红细胞寿命均缩短(P<0.05),4组患者红细胞寿命均较12例健康志愿者红细胞寿命(118.16±25.88)d显著缩短(P<0.01)。结论:红细胞寿命缩短参与了AIHA、MDS、SAA和IDA患者贫血的发生,但在不同贫血疾病中所起作用程度不尽相同。

Objective:To investigate the life span of red blood cells(RBC)in patients with autoimmune hemolytic anemia(AIHA),and compare with those of common anemia diseases.Methods:Clinical data of 55 patients in 4 groups with AIHA,myelodysplastic syndrome(MDS),severe aplastic anemia(SAA)and iron deficiency anemia(IDA)were retrospectively analyzed,and 12 healthy volunteers in the same period served as normal controls.The endogenous Breath Carbon Monoxide(CO)test was used to detect the life span of RBC,and the erythrocyte life span of patients in 4 different groups and healthy volunteers was observed and analyzed.Results:The erythrocyte life span of RBC in patients with MDS,SAA and IDA was(53.44±32.61),(54.53±22.56)and(58.75±31.29)days,respectively,which was significantly longer than that in the patients with AIHA[(30.41±31.12)days](P<0.05).The life span of RBC in the 4 groups was significantly shorter than that of the 12 normal volunteers[(118.18±25.88)days](P<0.01).Conclusion:The shortening of RBC life span is involved in the occurrence of anemia in patients with AIHA,MDS,SAA and IDA,but the role of erythrocyte life span varies with different diseases.