普罗布考联合阿托伐他汀对高龄患者颈动脉粥样硬化斑块的疗效及安全性

Efficacy and safety of probusco combined with atovastatin in treatment of carotid atherosclerotic plaque in very old patients

目的探讨普罗布考联合阿托伐他汀对高龄患者颈动脉粥样硬化斑块的临床疗效及安全性。方法入选2017年1月至2017年12月北京市和平里医院神经内科收治的高龄颈动脉粥样硬化伴斑块形成患者60例。随机数表法分为2组:联合用药组和对照组,每组30例。对照组口服阿托伐他汀,联合用药组患者在对照组基础上加用普罗布考。疗程36周。对比2组患者治疗前后各临床指标的变化。采用SPSS19.0软件进行数据处理。依据数据类型,组间比较分别采用t检验或χ^2检验。结果与对照组相比,治疗后联合用药组的总胆固醇[(3.42±1.63)vs(3.83±1.34)mmol/L]、甘油三酯[(1.80±1.37)vs(1.95±1.65)mmol/L]、低密度脂蛋白胆固醇[(2.13±1.32)vs(2.63±1.64)mmol/L]、神经元特异性烯醇化酶[(9.48±6.78)vs(12.31±9.78)mmol/L]、高敏C-反应蛋白[(3.42±1.36)vs(4.56±3.36)mmol/L]水平均显著下降(P<0.05),而高密度脂蛋白胆固醇[(1.64±1.01)vs(1.43±1.12)mmol/L]显著升高(P<0.05)。2组患者治疗前后各项安全性指标比较,差异均无统计学意义(P>0.05)。结论普罗布考联合阿托伐他汀可有效改善高龄患者颈动脉血流阻力指数,具有明显抗氧化、减轻神经损伤的作用,且临床应用安全性较好。

Objective To investigate the clinical efficacy and safety of probucol combined with atorvastatin in treatment of carotid atherosclerotic plaque in very old patients.Methods Sixty very old patients(≥80 years old)with carotid atherosclerotic plaques identified by ultrasonography admitted in our department from January 2017 to December 2017 were recruited in this study,and then randomly divided into control group(n=30)and combined treatment group(n=30).Both groups of patients were given oral administration of atorvastatin,while those from the combined treatment group were treated with combination of probucol.The related clinical indices were recorded before and after 36 weeks′treatment.SPSS statistics 19.0 was used to perform the statistical analysis.Chi-square test or Student′s t test was employed for comparison between the 2 groups based on different data types.Results The combined treatment group had significantly lower serum total cholesterol[(3.42±1.63)vs(3.83±1.34)mmol/L],triglycerides[(1.80±1.37)vs(1.95±1.65)mmol/L],low-density lipoprotein cholesterol[(2.13±1.32)vs(2.63±1.64)mmol/L],neuronal specific enolase[(9.48±6.78)vs(12.31±9.78)mmol/L]and high-sensitivity C-reactive protein[(3.42±1.36)vs(4.56±3.36)mmol/L],but obviously higher high-density lipoprotein cholesterol[(1.64±1.01)vs(1.43±1.12)mmol/L]when compared with the control group(all P<0.05).There was no significant differences in all indices concerning safety before and after treatment in the both groups(P>0.05).Conclusion Probucol combined with atorvastatin effectively improves the resistance indices of carotid artery in very old patients,and shows obvious protective effects on oxidation damage and nerve damage with good clinical safety.