摘要
长链脂肪酸是维持机体正常代谢的重要营养素,其吸收、转运和代谢对动物的健康、生长和生产具有重要意义。近年来,研究发现一些脂肪酸转运蛋白介导长链脂肪酸的跨膜转运。脂肪酸移位酶CD36/SR-B2是一种整合膜蛋白,能特异性介导脂肪酸在多种细胞中的跨膜转运。本文对CD36/SR-B2的由来、亚细胞定位、功能调控及其介导的长链脂肪酸跨膜转运进行概述,探讨其对脂质代谢的调控机制。
Long-chain fatty acids are important nutrients to maintain normal metabolism of the body,its absorption,transportation and metabolism have important influences on the health,growth and production of animals.In recent years,researchers have found that some fatty acid transporter proteins mediated the transportation of long-chain fatty acids across the membrane.The fatty acid translocase CD36/SR-B2 is an integrated membrane protein,which could specifically regulate the transmembrane transportation of fatty acids in many different types of cells.This paper reviewed the current understanding,subcellular localization,functional regulation of CD36/SR-B2 and the transmembrane transportation of long-chain fatty acids mediated by CD36/SR-B2,and also discussed the regulation mechanism of lipid metabolism by CD36/SR-B2.
作者
骆东梅
汪水平
赵雪莉
韩雪峰
LUO Dongmei;WANG Shuiping;ZHAO Xueli;HAN Xuefeng(College of Animal Science,Southwest University,Chongqing 402460,China;Key Laboratory for Agri-EcologicalProcesses in Subtropical Region,National Engineering Laboratory for Pollution Control and Waste Utilization inLivestock and Poultry Production,Hunan Research Center of Livestock and Poultry Sciences,South CentralExperimental Station of Animal Nutrition and Feed Science in Ministry of Agriculture,Institute ofSubtropical Agriculture,The Chinese Academy of Sciences,Changsha 410125,China;XishuiFuxing Husbandry Co.,Ltd.,Xishui 556400,China;Baiyu Muwang Agricultural Science andTechnology Co.,Ltd.,Baiyu 627150,China;Baiyu Yumu Fengyuan Animal HusbandryScience and Technology Co.,Ltd.,Baiyu 627150,China)
出处
《动物营养学报》
CAS
CSCD
北大核心
2019年第6期2552-2559,共8页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
国家自然科学基金项目(31872386)
四川省科技计划项目(2019YFN0080)
四川省政府采购项目(5133312018000053)
