克罗恩病的治疗药物以及单药与联合治疗的抉择

Therapeutic drugs of Crohn′s disease and the choice of single drug and combination therapy

克罗恩病是一种慢性非特异性肠道炎性病变,肠道病变多表现为溃疡、狭窄、穿透,临床上常表现为腹痛、腹泻、不全性肠梗阻及瘘管形成。克罗恩病是一种伴随终生的疾病,在疾病发生发展过程中,可发生多种并发症,有一定致残性。其治疗主要是以药物为主,在不同时期、不同疾病阶段应选择个体化治疗方案。本文阐述了克罗恩病的临床特点,重点阐述了其治疗药物的分类及药物治疗方案的选择,对于需要药物联合使用的情况进行了分析。

Crohn′s disease(CD) is a chronic non-specific intestinal inflammatory disease.The intestinal lesions are often characterized by ulceration,stenosis and perfiration.Abdominal pain,diarrhea,incomplete intestinal obstruction and fistula formation are common clinical manifestations.Crohn′s disease is a lifelong disease.During the development of the disease,various complications can occur and it has a certain degree of disability.The treatment of Crohn′s disease is mainly drugs based.Individualized treatment plans should be selected at different stages of disease in different periods.This article describes the clinical characteristics of Crohn′s disease,focusing on the classification of its therapeutic drugs and the choice of drug treatment options,especially for the analysis of the need for the combination of drugs.