肠愈宁治疗溃疡性结肠炎的疗效研究

Study on the clinical efficacy of Changyuning in the treatment of patients with ulcerative colitis

目的观察肠愈宁治疗活动期溃疡性结肠炎大肠湿热证患者的临床疗效。方法选择符合纳入标准的溃疡性结肠炎大肠湿热证的患者40例,予以肠愈宁治疗,疗程为4周。观察指标为治疗前、后的中医症状、体征及结肠镜下黏膜病理变化,血清C反应蛋白及免疫球蛋白G变化情况,并对其结果进行统计学分析。结果肠愈宁治疗溃疡性结肠炎大肠湿热证的临床总有效率、中医证候总有效率及结肠镜下肠黏膜病变的总有效率分别是86.49%、89.19%、83.78%。治疗后,中医证候总积分显著降低,血清CRP、IgG水平明显降低,且差异有统计学意义(P<0.05)。结论肠愈宁治疗溃疡性结肠炎大肠湿热证患者的临床疗效显著。

Objective To observe the clinical efficacy of Changyuning in the treatment of active ulcerative colitis(UC) with colorectal dampness-heat syndrome.Methods Forty patients with UC with colorectal dampness-heat syndrome who met the inclusion criteria were enrolled and treated with Changyuning for 4 weeks.The changes in clinical efficacy,signs and symptoms of traditional Chinese medicine(TCM),histopathological changes under colonoscopy,and the levels of serum C-reactive protein(CRP) and immunoglobulin G(IgG) of patients before and after treatment were observed and analyzed.Results The clinical total effective rate of Changyuning in the treatment of UC with colorectal dampness-heat syndrome was 86.49%,the total effective rate of TCM syndrome and intestinal mucosal lesions under colonoscopy was 89.19% and 83.78%,respectively.After treatment,the total score of TCM syndrome and the serum levels of CRP and IgG were decreased significantly(P<0.05).Conclusion The effect of Changyuning is remarkable in the treatment of patients with UC with colorectal dampness-heat syndrome.