纳米载药系统靶向肿瘤相关巨噬细胞用于肿瘤治疗的研究进展

Advances in Nanomedicine Strategies to Target Tumor-associated Macrophage

肿瘤相关巨噬细胞(tumorassociatedmacrophage,TAM)是肿瘤微环境内一类重要的免疫细胞,对肿瘤的发生、发展均具有重要影响。以TAM为靶点的肿瘤免疫治疗是肿瘤治疗的前沿和研究热点。纳米载药系统由于优良的理化性质为靶向调控TAM提供了新的思路和方向。本文阐述了以TAM为靶点的肿瘤治疗及纳米材料调控TAM杀伤肿瘤细胞的新策略。

Tumor associated macrophage (TAM),one of the most important immune cells in tumor microenvironment,plays an important part in the occurrence and development of tumor.TAM-targeted immunotherapy is the frontier and hotspot of tumor therapy.Due to its excellent physical and chemical properties,nano-drug delivery system provides a new idea and direction for targeted regulation of TAM.In this paper,the current situation of targeted regulation of TAM by nanomaterials to kill tumor cells is reviewed.