口腔来源蛋白及多肽诱导牙釉质仿生矿化的研究进展

Research Progress on Biomimetic Enamel Mineralization Induced by Proteins and Peptides from Oral Cavity

牙釉质生物矿化过程中,成釉细胞分泌各种蛋白介导有序棱柱状羟磷灰石晶体的形成,最终形成高度复杂而有序的牙釉质结构。当牙釉质结构遭到破坏后,寻求可诱导釉质微结构再生的仿生修复材料和方法是目前牙体修复研究的一大难点和热点。利用口腔来源的蛋白及多肽人工诱导牙釉质矿化过程,以实现牙釉质结构再生的仿生矿化修复被认为是一种很有前景的治疗手段。本文就近年来口腔来源的蛋白及其多肽诱导牙釉质仿生矿化的相关研究作一综述。

During enamel biomineralization,ameloblasts secrete proteins to mediate the hydroxyapatite crystallites to form the well-organized prism pattern.Finally,a highly complex and ordered enamel structure is formed.When the enamel is destructed,it is of great difficulties and high popularity to find biomimetic reparative materials or methods that can induce the regeneration of enamel microstructure at present.Among them,enamel biomimetic mineralization using proteins derived from oral environment and their derived peptides is a promising way to rebuild the enamel.In this paper,we review the advancement of enamel biomimetic mineralization induced by proteins and their derived peptides from oral cavity according to the latest reports in recent years.