长链非编码RNA对原发性肝癌中糖酵解途径的影响机制

Effect of long non-coding RNAs on glycolytic pathway in primary liver cancer and related mechanisms

原发性肝癌发病机制复杂,具有起病隐匿、恶性程度高、预后差等特点。而肿瘤细胞与正常细胞的区别之一在于糖代谢途径的改变,肿瘤细胞优先选择糖酵解途径提供能量。有氧糖酵解则常与原发性肝癌的进展及预后不良有关。长链非编码RNA在众多肿瘤中通过调节糖摄取率、糖酵解酶的表达及活性,影响糖酵解途径,并在原发性肝癌的发生及进展中起着重要的调节作用,提示其可以作为肝癌的治疗靶点。总结了长链非编码RNA对原发性肝癌及糖代谢的影响机制,旨在为原发性肝癌寻找潜在有效的靶向治疗。

Primary liver cancer is a common malignant tumor with complex pathogeneses and has the features of insidious onset,high degree of malignancy,and poor prognosis.The change in glycolytic pathway is one of the most important differences between tumor cells and normal cells,and tumor cells prefer to generate energy from glycolysis.Aerobic glycolysis is often associated with the progression and poor prognosis of primary liver cancer.Long non-coding RNAs(lncRNAs) can influence the glycolysis pathway in many tumors by regulating glucose uptake and the expression and activation of glycolytic enzymes and thus play an important role in the development and progression of primary liver cancer,which suggests that lncRNAs can be used as a therapeutic target for liver cancer.This article summarizes the influence of lncRNAs on primary liver cancer and glucose metabolism and related mechanisms,so as to find potential and effective targeted therapies for primary liver cancer.