肌少症与非酒精性脂肪性肝病存在独立相关性

Independent association between sarcopenia and nonalcoholic fatty liver disease

非酒精性脂肪性肝病是一种可进展为肝纤维化、肝硬化及肝癌的代谢性疾病,肌少症是一种增龄相关性疾病,代谢相关因素在其发生中也发挥了重要作用,两者共享多种代谢性病理生理机制。非酒精性脂肪性肝病与肌少症之间是否具有相关性、是否互为诱因或互为疾病进展危险因素尚需进一步研究,以帮助临床更好的对两者进行预防、治疗及预后评估。就非酒精性脂肪性肝病与肌少症的独立相关性进行综述。

Nonalcoholic fatty liver disease(NAFLD) is a metabolic disease which can progress to liver fibrosis,liver cirrhosis,and liver cancer.Sarcopenia is an age-related disease and metabolic factors play an important role in its pathogenesis.NAFLD and sarcopenia share a variety of metabolic pathophysiological mechanisms.Further studies are needed to determine whether there is an association between NAFLD and sarcopenia and whether they are predisposing factors or risk factors for disease progression for each other,in order to help with better prevention,treatment,and prognostic evaluation of the two diseases in clinical practice.This article reviews the independent association between NAFLD and sarcopenia.