自身免疫性肝炎相关自身抗体及临床意义

Autoimmune hepatitis-related autoantibodies and their clinical significance

自身免疫性肝炎(AIH)是一种靶向肝细胞、自身免疫反应介导的肝脏实质炎症,以血清中存在自身抗体及高IgG和(或)高γ-球蛋白血症为特征。大多数AIH患者血清中存在一种或多种自身抗体,这些自身抗体是AIH的重要特征和诊断的重要依据,部分自身抗体还与AIH的不同临床表现、疾病活动、治疗应答以及预后相关。对AIH相关自身抗体及其临床意义进行了探讨。

Autoimmune hepatitis(AIH) is an autoimmune response-mediated liver parenchymal inflammation targeting hepatocytes,with the features of autoantibodies in serum,a high serum level of immunoglobulin G,and/or hypergammaglobulinemia.Most AIH patients have one or more autoantibodies in serum,and these antibodies are important features of AIH and the basis for the diagnosis of AIH.Some antibodies are also associated with the clinical manifestations,disease activity,therapeutic response,and prognosis of AIH.This article reviews AIH-related autoantibodies and their clinical significance.