细胞凋亡在原发性胆汁性胆管炎发病机制中的作用

Role of cell apoptosis in the pathogenesis of primary biliary cholangitis

细胞凋亡在肝脏疾病的发生发展及内环境稳定中发挥着重要作用。在原发性胆汁性胆管炎中,胆管上皮细胞可能导致线粒体自身抗原的直接特异性免疫应答。死亡受体的激活、氧化应激、感染和毒素等信号,均可使胆管上皮细胞在凋亡过程中受到免疫攻击的选择性损伤。细胞的生存调节失常,会引起小胆管以细胞凋亡为主要方式逐渐丧失,最终引起原发性胆汁性胆管炎。讨论了细胞凋亡在原发性胆汁性胆管炎发生发展中的作用。

Cell apoptosis plays an important role in the development and progression of liver diseases and the maintenance of liver homeostasis.In primary biliary cholangitis,biliary epithelial cells can lead to the specific immune response of mitochondrial autoantigens.The signals such as the activation of death receptor,oxidative stress,infection,and toxin may cause selective damage of biliary epithelial cells by immune attack during cell apoptosis.Abnormal survival regulation of cells may result in a gradual loss of small bile ducts mainly in the way of cell apoptosis and may eventually lead to the development of primary biliary cholangitis.