皮肤致敏试验替代方法研究进展

Research progress on alternative methods for skin sensitization tests

概述并比较分析了直接肽反应试验(DPRA)、小鼠局部淋巴结试验(LLNA)、KerationSens^TM、人细胞系激发试验(h-CLAT)和重组人表皮致敏试验等皮肤致敏试验替代方法,并重点介绍了各替代方法的整合研究情况,提出了皮肤致敏试验替代方法的发展前景。

In the present study, skin sensitization alternative methods, such as direct peptide reactivity assay(DPRA), local lymph node assay(LLNA), KerationSens^TM, human cell line activation test(h-CLAT)and reconstructed human epidermis model(RHE model)sensitization test, were summarized, analyzed and compared. The integration of these alternative methods was introduced, and the development prospects of alternative methods for skin sensitization test were prospected.