盐霉素类似物的分离及抑制吲哚胺2,3-双加氧酶活性研究

Study on the isolation and indoleamine 2,3-dioxygenase inhibitory activity of salinomycin analogues

为研究盐霉素发酵粗产物中的新型盐霉素类活性化合物。实验通过制备色谱从盐霉素发酵粗产物中分离得到两个盐霉素类似物,并利用波谱手段表征了这两个化合物的结构,化合物A为40-甲基盐霉素,化合物B为35-甲基盐霉素,均为新化合物。生物活性研究表明,化合物B具有一定的吲哚胺2,3-双加氧酶(IDO)抑制活性。

To study the novel salinomycin analogues in the salinomycin fermentation product,in this work,two salinomycin analogues were prepared from the salinomycin fermentation product by preparative chromatography and subsequently characterized by spectroscopic means.Compound A was found to be 40-methyl salinomycin and compound B was found to be 35-methyl salinomycin,both of the analogues were new compounds.Biological activity studies indicated that compound B exhibited inhibitory activity against indoleamine 2,3-dioxygenase(IDO).