18F-FDG PET/CT与DWI-MRI判断鼻咽癌放疗后残留/复发价值的Meta分析

18F-FDG PET/CT Versus DWI-MRI in detecting residue or recurrence of nasopharyngeal carcinoma after radiotherapy:a Meta analysis

目的对比18F-FDGPET/CT(PET/CT)和扩散加权成像(DWI)判断鼻咽癌放疗后局部残留/复发的价值。方法检索PubMed、CochraneLibrary、Embase、中国生物医学文献数据库、中国学术期刊全文数据库,获取相关文献,末次检索时间为2017年7月。两名研究者独立筛选文献和提取数据,并根据诊断准确性研究质量评价工具(QUADAS-2)标准评价文献质量,通过STATA15.0软件计算出PET/CT和DWI的合并敏感度、特异度、汇总受试者工作特征(SROC)曲线和Q*值。结果11项PET/CT和9项DWI研究纳入分析,PET/CT与DWI的汇总的敏感度分别为92%(95%CI:0.87~0.95)和88%(95%CI:0.83~0.92),汇总的特异度分别为85%(95%CI:0.75~0.91)和87%(95%CI:0.80~0.92),受试者工作曲线(SROC)曲线下面积均为0.94,比较差异无统计学意义(P>0.05),Q*值分别为0.89、0.87。结论PET/CT与DWI在诊断鼻咽癌放疗后残留/复发的诊断价值无明显区别。

Objective To compare the value of 18 F-FDG PET/CT (PET/CT) with diffusion weighted imaging (DWI) in detecting local residue/recurrent of nasopharyngeal carcinoma after radiotherapy.Methods PubMed,Cochrane Library,Embase,Sinomed and China Jornal Full-text Database (CJFB) were searched,and the last retrieval time was July 2017.Two researchers independently screened the literature and extracted data,and methodological quality was assessed using QUADAS-2.Pooled sensitivity,pooled specificity,summary receiver operating characteristic (SROC) curves and Q * value were obtained using STATA 15.0 software.Results A total of 11 PET/CT and 9 DWI studies were included in the Meta-analysis.The pooled sensitivity for PET/CT and DWI-MRI were 92%(95% CI :0.87-0.95)and 88%(95% CI :0.83-0.92).The pooled specificity were 85%(95% CI :0.75-0.91) and 87%(95% CI :0.79-0.92).Area under SROC curve of PET/CT and DWI were 0.94 and 0.94( P >0.05).The Q* value for PET/CT and DWI-MRI were 0.89 and 0.87.Conclusion There were no significant differences between PET/CT and DWI in detecting local residual/recurrent nasopharyngeal carcinoma after radiotherapy.