缺血性脑卒中合并脑微出血患者认知功能及血清细胞因子变化的研究

Study on changes of cognitive function and serum cytokine in patients with ischemic stroke complicated with cerebral microbleeds

目的探讨缺血性脑卒中合并脑微出血(CMB)患者的认知功能及血清中白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的变化情况。方法回顾性分析该院神经内科2017年1-12月收治的88例缺血性脑卒中患者的临床资料,根据患者是否合并CMB分为CMB组和非CBM组,每组各44例。对所有患者的认知功能进行蒙特利尔量表认知功能评分,均采酶联免疫吸附试验(ELISA)检测血清中IL-1β、IL-6、TNF-α水平。结果CMB组患者抽象思维、注意力与计算力、视空间执行、记忆力、定向力、语言等认知功能评分均显著低于非CBM脑卒中组,两组间比较差异均有统计学意义(P<0.05);CMB组血清中IL-1β、IL-6、TNF-α水平均高于非CBM组,两组间比较差异均有统计学意义(P<0.05)。结论缺血性脑卒中合并CMB患者的认知功能减退,血清中IL-1β、IL-6、TNF-α水平较单纯缺血性脑卒中组升高。

Objective To investigate the changes of cognitive function,serum IL-1β,IL-6 and TNF-α in the patients with cerebral ischemic stroke complicating cerebral microbleeding (CMB). Methods The clinical data in 88 cases of cerebral ischemic stroke in the neurosurgery department of this hospital from January to December 2017 were retrospectively analyzed.The patients were divided into the non-CMB group and CMB group according to whether complicating CMB,44 cases in each group.The Montreal cognitive assessment was performed for the cognitive function evaluation in all cases.The levels of serum IL-1β,IL-6 and TNF-α were detected by adopting ELISA. Results The cognitive function scores of abstract thinking,attention,computing power,visual space execution,memory,orientation and language in the CMB group were significantly lower than those in the non-CMB group,and the differences between the two groups were statistically significant ( P < 0.05).The levels of serum TNF-α,IL-1β and IL-6 in the CMB group were higher than those in the non-CMBs group,and the differences between the two groups were statistically significant ( P <0.05). Conclusion The cognitive functions of the patients with cerebral ischemic stroke complicating CMB is declined and the levels of serum TNF-α,IL-1β and IL-6 are increased compared with the simple cerebral ischemic stroke group.