基于OMOP通用数据模型的FAERS数据库标准化与数据挖掘

Standardization and Data Mining of FAERS Database Based on OMOP Common Data Model

应用 OMOP 通用数据模型,对 FAERS 数据库进行标准化转化,通过标准化前后数据质量与数据采集速度的对比分析,展示 OMOP CDM 在 FAERS 数据标准化程中的重要意义。然后,标准化的基础上,对 5-羟色胺再摄取抑制剂(Selective Serotonin Reuptake Inhibitor,SSRIs)药物不良反应信号进行了挖掘,展示了基于“真实世界数据”的SSRIs 上市后的安全信号的综合挖掘结果,为后续用药研究提供参考。

In this study, we utilize OMOM Common Data Model to standardize FAERS data set. And then we evaluate the transformation results to validate the significance of the FAERS standardization. Then, we implement a data mining research about 5 Selective Serotonin Reuptake Inhibitor (SSRIs) drugs base on the standardized FAERS database. The study based on ADR signals in the real world is helpful to evaluate the post-marking safety drugs and provide references for safety in clinical medication.