椎间盘退变动物模型的研究进展

Current status of research on animal models of intervertebral disc degeneration

椎间盘退变是腰痛发生的主要原因,严重影响了人们的生活和工作。尽管具体发病机制尚不明确,但近年来其相关动物模型的研究有了很大的进步。造模方法包括结构损伤、应力改变及基因敲除等,本文综述并讨论了这些方法的优缺点和应用方向,以期为后续的研究奠定理论基础。

Degeneration of intervertebral discs is a major cause of lower back pain that seriously affects quality of life and productivity.Although the specific pathogenesis is still unclear,recent research of related animal models has made great progress.The modeling method include structural damage,stress changes,and gene knockout.In this review,we focus on the advantages and disadvantages of these methods and their applications to establish a theoretical foundation for subsequent research.