腰痛相关动物模型的研究进展

Research progress on animal models of low-back pain

腰痛(low back pain,LBP)是影响人类健康的最常见疾病之一,患病率高且治愈率低下。其发病机制尚不清楚,可能与多种因素有关,如椎间盘退变、关节突关节损伤、肌肉筋膜炎症等。建立恰当的动物模型有助于研究和了解LBP的发病机制、探索预防及治疗方法。本文就可诱发腰痛的动物模型研究进展综述如下。

Low-back pain (LBP) is common and the cure rate is low.Its mechanism of action is incompletely understood and may be related to degeneration of intervertebral disks,facet-joint injury,or inflammation of muscle fascia.Establishing an appropriate animal model can help to study and understand the pathogenesis of LBP,as well as explore its prevention and treatment methods.This article summarizes the research progress of animal models which can be used to induce low-back pain.