步长脑心通胶囊治疗高脂血症的系统评价

Buchang Naoxintong Capsule in the Treatment of Hyperlipidemia:a Systematic Review

目的 系统评价步长脑心通胶囊治疗高脂血症的疗效和安全性。方法 计算机检索Cochrane图书馆、PubMed、EMbase、Medline、CNKI、CBM、VIP、万方数据库等数据库,纳入相关随机对照试验(RCT),并进行评价,采用RevMan5.3软件分析数据。结果 纳入35篇RCT,共3855例受试者。相比常规治疗或单独使用西药治疗(对照组),步长脑心通胶囊治疗(试验组)的血脂总疗效高于对照组[RR=1.21,95%CI(1.15,1.28),P<0.00001],治疗后总胆固醇(TC)水平低于对照组[WMD=-0.77,95%CI(-0.91,-0.64),P<0.00001],治疗后三酰甘油(TG)水平低于对照组[WMD=-0.58,95%CI(-0.68,-0.48),P<0.00001],治疗后高密度脂蛋白(HDL-C)高于对照组[WMD=0.20,95%CI(0.13,0.27),P<0.00001],治疗后低密度脂蛋白胆固醇(LDL-C)水平低于对照组[WMD=-0.58,95%CI(-0.73,-0.43),P<0.00001],各组不良反应发生率差异无统计学意义[RR=0.85,95%CI(0.58,1.24),P=0.40]。结论 步长脑心通胶囊治疗高脂血症疗效明显,对TC、TG、HDL-C、LDL-C的改善均较有效,不良反应发生率未见与其他药物有明显差异。

Objective To systematically evaluate the efficacy and safety of Buchang Naoxintong capsule (BNC) in the treatment of hyperlipidemia. Methods The literatures were retrieved from the Cochrane Library,PubMed,Embase,Medline,China National Knowledge Infrastructure Database (CNKI),China Biology Medicine (CBM) database,VIP,and Wanfang database.The relevant randomized controlled trials (RCTs) were enrolled,and analyzed by RevMan5.3 software. Results Thirty-five RCTs were enrolled,involving 3 855 subjects.Compared with the basic treatment or western medicine group,the total effective ratt of lipid in BNC group was higher than that in the control group [RR=1.21,95% CI (1.15,1.28), P <0.000 01].The total cholesterol (TC) level in BNC group after treatment was lower than that in the control group [WMD=-0.77,95% CI (-0.91,-0.64), P <0.000 01].The level of triglyceride (TG) in BNC group after treatment was lower than that in the control group [WMD=-0.58,95% CI (-0.68,-0.48), P <0.000 01].The level of high-density lipoprotein-cholesterol (HDL-C) in BNC group after treatment was higher than that in the control group [WMD=0.20,95% CI (0.13,0.27), P <0.000 01].The level of low-density lipoprotein-cholesterol (LDL-C) in BNC group after treatment was lower than that in the control group [WMD=-0.58,95% CI (-0.73,-0.43), P <0.000 01].There was no difference in the incidence of adverse reactions between the groups [RR=0.85,95% CI (0.58,1.24), P =0.40]. Conclusion BNC can effectively improve hyperlipidemia ,including TC,TG,HDL-C and LDL-C,The incidence of adverse reactions is not significantly different from other drugs.It is recommended for clinical application in the treatment of hyperlipidemia.It is recommended to supplement primary hyperlipidemia and more high-quality related research.