替加氟治疗晚期胃癌化疗患者的效果评价

Evaluation of the efficacy of tegafur in the treatment of advanced gastric cancer patients

目的 探讨替加氟治疗晚期胃癌化疗患者的临床效果。方法 将65例晚期胃癌患者随机分为对照组32例,观察组33例。两组患者均予以奥沙利铂+亚叶酸钙化疗,在此基础上对照组患者采用5-氟尿嘧啶化疗,观察组予以替加氟治疗。比较两组患者的治疗效果。结果 观察组患者治疗效果优于对照组(P<0.05);两组各项不良反应发生率对比无明显差异(P>0.05),但观察组1年、2年生存率均高于对照组(P<0.01)。结论 替加氟治疗晚期胃癌化疗患者效果确切,预后良好,值得推广。

Objective To investigate the clinical effect of tegafur in the treatment of advanced gastric cancer patients.Methods Sixty-five patients with advanced gastric cancer were randomly divided into control group(n=32)and observation group( n= 33).Both the groups received oxaliplatin and leucovorin chemotherapy.Besides the above drugs,the control group received 5-fluorouracil chemotherapy,while the observation group did tegafur therapy.The therapeutic efficacy of the two groups were compared.Results The observation group achieved a better efficacy than that of the control group ( P <0.05).No significant difference in the incidence of adverse reactions existed between the two groups.The observation group obtained higher 1-year and 2-year survival rates than those of the control group( P <0.01).Conclusion Tegafur is effective in treating advanced gastric cancer patients with a good prognosis.