CIS患者血清CXCL16 Lp-PLA2 IL-6及MMP-9的变化及意义

Changes of serum CXCL16,Lp-PLA2,IL-6,MMP-9 in CIS patients and its relationship with TOAST classification and NIHSS score

目的 探讨缺血性脑卒中(CIS)患者血清CXC趋化因子16(CXCL16)、脂蛋白相关磷脂酶(Lp-PLA2)、白细胞介素 6(IL-6)、基质金属蛋白酶 9(MMP-9)的变化及意义。方法 选取安阳市第三人民医院2016 06—2018 01收治的140例CIS患者(CIS组),选取年龄、性别相匹配的70例非CIS患者(对照组),检测并比较2组血清CXCL16、Lp-PLA2、IL-6、MMP-9水平,并根据TOAST分型进行分层分析,探讨各项指标与神经功能缺损评分(NIHSS)的相关性。结果 CIS组患者血清CXCL16、Lp-PLA2、IL-6、MMP-9水平均显著高于对照组,差异有统计学意义(P <0.05);不同TOAST分型CIS患者血清Lp-PLA2、IL-6、MMP-9水平组间比较,差异有统计学意义(P <0.05);大动脉粥样硬化组、小动脉闭塞组血清Lp-PLA2、MMP-9水平高于心主动脉栓塞组(P <0.05),大动脉粥样硬化组血清Lp-PLA2、MMP-9水平高于小动脉闭塞组(P <0.05);大动脉粥样硬化组、心主动脉栓塞组血清IL-6水平高于小动脉闭塞组(P <0.05),心主动脉栓塞组血清IL-6水平高于大动脉粥样硬化组(P <0.05);CIS患者血清CXCL16、Lp-PLA2、MMP-9水平与患者NIHSS评分呈显著正相关(P <0.05),CIS患者血清IL-6水平与患者NIHSS评分无显著相关性(P >0.05)。结论 CIS患者血清CXCL16、Lp-PLA2、IL-6、MMP-9水平显著升高,且与TOAST分型、神经功能损伤程度关系密切。

Objective To investigate the serum CXC chemokine 16 (CXCL16),lipoprotein related phospholipase (Lp-PLA2),interleukin-6 (IL-6),matrix metalloproteinase-9 (MMP-9) in patients with ischemic stroke (CIS) changes and their significance. Methods Fourty four CIS patients (CIS group) who were admitted to our hospital were selected,and 70 non CIS patients (control group) with matched age and gender were selected.The serum CXCL16,Lp-PLA2,and the two groups were detected and compared.Levels of IL-6 and MMP-9 were stratified according to the TOAST classification,and the correlation between each index and the neurological deficit score (NIHSS) was explored. Results The serum levels of CXCL16,Lp-PLA2,IL-6 and MMP-9 in patients with CIS were significantly higher than those in the control group (P <0.05);serum Lp-PLA2 in patients with different TOAST subtypes of CIS There was a statistically significant difference between the IL-6 and MMP-9 levels (P <0.05).The levels of Lp-PLA2 and MMP-9 in the large atherosclerosis group and the small artery occlusion group were higher than those in the aortic embolization.In the group (P <0.05),serum Lp-PLA2 and MMP-9 levels in the atherosclerotic group were higher than in the small artery occlusion group (P <0.05);serum IL-6 in the aortic atherosclerosis group and aortic embolization group The level of serum IL-6 in the cardiac aortic embolization group was higher than that in the large atherosclerotic group (P <0.05);serum Lp-PLA2,IL-6,MMP in CIS patients was higher than in the small artery occlusion group (P <0.05).The level of MMP-9 was positively correlated with the NIHSS score of patients (P <0.05).There was no significant correlation between serum IL-6 levels and NIHSS scores of patients with CIS (P >0.05). Conclusion Serum CXCL16,Lp-PLA2,IL-6,MMP-9 levels were significantly elevated in CIS patients,and were closely related to TOAST classification and neurological impairment.