阿米替林联合多潘立酮治疗功能性消化不良的临床疗效

Efficacy of amitriptyline and domperidone in treatment of functional dyspepsia

目的探讨功能性消化不良给予多潘立酮联合阿米替林治疗的临床疗效。方法选择我院2016年6月至2019年1月收治的70例功能性消化不良患者,按照随机数字表法分为对照组和观察组,各35例。对照组给予多潘立酮治疗,观察组给予多潘立酮联合阿米替林治疗,比较2组胃肠激素水平、症状积分变化情况及疗效。结果观察组治疗总有效率(100%,35/35)较对照组(86%,30/35)高,治疗后生长抑素较对照组低,胃蛋白酶原、5羟色胺及胃动素均较对照组高,各症状积分均较对照组低,组间比较差异具有统计学意义(P<0.05)。结论功能性消化不良患者给予多潘立酮联合阿米替林治疗的疗效显著,可有效改善胃肠激素水平,降低各症状积分。

Objective To study the effect of amitriptyline and domperidone on symptom of functional dyspepsia (FD).Methods Seventy cases of FD from June 2016 to January 2019 were divided into two groups by random number table method,with 35 cases in each group.Control group was treated by domperidone,observation group was treated by domperidone and amitriptyline.Gastrointestinal hormones,symptom score,efficacy of two groups were compared.Results The total effective rate of observation group(100%,35/35)was higher than that of control group(86%,30/35),the somatostatin of observation group was lower than that of control group,the level of the pepsinogen,5-hydroxytryptamine and motilin of observation group were higher than that of control group,the symptom score was lower than that of control group (P<0.05).Conclusion Domperidone and amitriptyline for FD treatment is effective,it can improve levels of gastrointestinal hormones and decrease symptom score.