2型糖尿病合并冠心病患者PCT、hs-CRP及血脂水平与冠状动脉病变的相关性研究

Relationship between PCT, hs-CRP, Lipid Levels and Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus and Coronary Atherosclerotic Heart Disease

目的:探讨2型糖尿病合并冠心病(coronary heart disease, CHD)患者的降钙素原(procalcitonin, PCT)、超敏C-反应蛋白(hypersensitive C-reactive protein, hs-CRP)及血脂水平与冠状动脉病变的相关性。方法:选取2016年7月-2018年2月收治的178例2型糖尿病,根据冠状动脉造影检查结果,将合并CHD的2型糖尿病患者作为观察组( n =126),将单纯2型糖尿病患者作为对照组( n =52)。比较两组PCT、hs-CRP及血脂[甘油三酯(triglycerides, TG)、总胆固醇(total cholesterol, TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol, LDL-C)和高密度脂蛋白胆固醇(high density lipoprotein cholesterol, HDL-C)]水平,检测不同冠状动脉病变支数和Gensini评分的2型糖尿病合并CHD患者的PCT、hs-CRP及血脂水平,分析2型糖尿病合并CHD患者PCT、hs-CRP及血脂水平与冠状动脉病变的相关性。结果:与对照组比较,观察组PCT、hs-CRP、TG、TC、LDL-C水平升高,HDL-C水平降低,差异均有统计学意义( P <0.01)。随着冠状动脉病变支数及Gensini评分的增加,2型糖尿病合并CHD患者的PCT、hs-CRP、TG、TC、LDL-C水平逐渐升高,HDL-C水平逐渐降低,差异均有统计学意义( P <0.05)。Pearson相关性分析结果显示,2型糖尿病合并CHD患者的PCT、hs-CRP、TG、TC、LDL-C水平与冠状动脉病变支数及Gensini评分呈正相关,HDL-C水平与冠状动脉病变支数及Gensini评分呈负相关。结论:2型糖尿病合并CHD患者血清PCT、hs-CRP、TG、TC、LDL-C水平随着冠状动脉病变程度的加重而逐渐升高,提示早期实验室检测有助于评估2型糖尿病合并CHD患者的冠状动脉病变程度。

Objective To examine the levels of calcitonin (PCT), hypersensitivity C reactive protein (hs-CRP) and blood lipid levels in patients with type 2 diabetes mellitus (T2DM) and coronary atherosclerotic heart disease (CHD), and to explore their relationship with coronary artery disease. Methods A total of 178 patients with T2DM treated from July 2016 to February 2018 were selected. According to the results of coronary angiography, patients with T2DM and CHD were selected as observation group ( n =126), and patients with T2DM alone were selected as control group ( n =52). PCT, hs-CRP and blood lipid levels [triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C)] were compared between the two groups, and the levels of the above indicators in T2DM patients with different number of coronary artery lesions and Gensini scores were detected. The correlation between PCT, hs-CRP, blood lipid levels and coronary artery lesions in T2DM patients with CHD was analyzed. Results Compared with the control group, the levels of PCT, hs-CRP, TG, TC and LDL-C were increased and HDL-C was decreased in the observation group, with statistical significance ( P <0.01). The levels of PCT, hs-CRP, TG, TC and LDL-C in patients with T2DM complicated with CHD were gradually increased and the levels of HDL-C were gradually decreased with the increase in the number of coronary artery lesions and Gensini score ( P <0.05). Pearson correlation analysis showed that the levels of PCT, hs-CRP, TG, TC, and LDL-C in T2DM patients with CHD were positively correlated with the number of coronary artery lesions and Gensini score, while the levels of HDL-C were negatively correlated with the number of coronary artery lesions and Gensini score. Conclusion The levels of serum PCT, hs-CRP, TG, TC, and LDL-C in T2Dm patients with CHD were increased gradually with the severity of coronary artery lesions. Early detection of serum PCT, hs-CRP and blood lipids is helpful to evaluate the extent and severity of coronary artery lesions in T2DM patients with CHD.