血清中IL-6、IL-1β、GM-CSF在老年急性痛风性关节炎患者中的变化及意义

Changes and Significance of Serum IL-6,IL-1β and GM-CSF in Elderly Patients with Acute Gouty Arthritis

目的探究血清中白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、粒细胞-巨噬细胞集落刺激因子(GM-CSF)在老年急性痛风性关节炎(AGA)患者中的变化及意义。方法回顾性分析我院收治的94例AGA患者病历资料,依据病情严重程度分为急性期组(47例)和缓解期组(47例),同期选取47例健康志愿者作为对照组。采集所有研究对象血液,采用酶联免疫吸附法(ELISA)检测其血清中的IL-6、IL-1β、GM-CSF等细胞因子水平并进行分析。结果急性期组IL-6、IL-1β、GM-CSF水平均显著高于缓解期组和对照组(P均<0.05),缓解期组IL-6、IL-1β、GM-CSF水平均显著高于对照组(P均<0.05);血清的IL-6、IL-1β、GM-CSF等指标水平与AGA呈正相关。结论在AGA患者的血清中,IL-6、IL-1β、GM-CSF水平可出现明显升高,且其升高程度与疾病活动性呈显著正相关,在疾病的早期诊断、鉴别分期及判断预后中均具有重要临床意义。

Objective To explore the changes and significance of serum interleukin-6(IL-6),interleukin-1β(IL-1β) and granulocyte-macrophage colony-stimulating factor (GM-CSF) levels in elderly patients with acute gouty arthritis (AGA). Methods The medical records of 94 patients with AGA admitted to our hospital were retrospectively analyzed.According to the severity of the disease,the patients were divided into acute phase group (47 cases) and remission group (47 cases).In addition,47 healthy volunteers were selected as control group.The blood samples of all subjects were collected,and the serum levels of IL-6,IL-1β,GM-CSF and other cytokines were detected by enzyme-linked immunosorbent assay and analyzed. Results The levels of IL-6,IL-1β and GM-CSF in the acute phase were significantly higher than those in the remission group and in the control group( P <0.05),and the levels of IL-6,IL-1β and GM-CSF in the remission group were significantly higher than those in the control group( P <0.05).The levels of serum IL-6,IL-1β,GM-CSF and other indicators were positively correlated with AGA. Conclusion In the serum of AGA patients,the levels of IL-6,IL-1beta and GM-CSF can be significantly increased,and the degree of increase is positively correlated with disease activity.It has important clinical significance in the early diagnosis,differential staging and prognosis of the disease.