脐血干细胞移植治疗非血液学疾病的临床研究进展

Clinical progress in the treatment of non-hematopoietic diseases by human umbilical cord blood cell transplantation

背景:人类脐血中含有大量干细胞,这些干细胞在体内外具有分化成为造血、上皮、内皮、神经等多种组织的能力,因此脐血具有治疗多种疾病的潜能。目的:综述脐血干细胞治疗各种非血液学疾病的临床应用研究进展。方法:以"umbilical cord stem cells,umbilical cord blood mesenchymal stem cells,umbilical cord blood"等为关键词检索PubMed等外文数据库,以"脐血干细胞、脐血间充质干细胞、临床研究"等关键词检索CNKI等中文数据库从2001年至今的相关文献,排除与文章研究目的无关及重复性文章,纳入符合标准的64篇文献进行综述。结果与结论:脐血干细胞的临床研究涉及到循环系统、内分泌系统、神经系统等多个领域,且多数已经取得了良好的试验结果,相信随着脐血生物学和免疫特性的基础研究以及临床研究的深入,脐血干细胞的临床应用前景必将更为广阔,成为更多患者的一种新的治疗选择。

BACKGROUND: Human umbilical cord blood contains a large number of stem cells that are capable of differentiating into hematopoietic, epithelial, endothelial and neural tissues both in vitro and in vivo. Thus, human umbilical cord blood has a therapeutic potential to a wide variety of diseases.OBJECTIVE: To summarize the clinical application of human umbilical cord blood cells in the treatment of non-hematopoietic diseases.METHODS: A computer-based retrieval of PubMed and CNKI databases was performed in order to search relevant articles published from 2001 till now, using the keywords of "umbilical cord stem cells, umbilical cord blood mesenchymal stem cells, umbilical cord blood" in English and Chinese, respectively. After removal of repetitive or irrelevant articles, 64 articles were finally reviewed.RESULTS AND CONCLUSION: The clinical research of umbilical cord blood stem cells involves many fields such as the circulatory system,endocrine system and nervous system, in most of which good experimental results have been achieved. Findings from in-depth basic and clinical studies on biological and immunological characteristics of cord blood indicate an extensive application of umbilical cord blood stem cells that will be a new therapeutic choice for patients.