玻璃酸钠和曲安奈德治疗膝关节骨性关节炎的疗效比较

An Efficacy Comparison of Sodium Hyaluronate and Triamcinolone Acetonide in Osteoarthritis of the Knee Treatment

目的:比较关节腔内注射玻璃酸钠和曲安奈德治疗膝关节骨性关节炎的疗效。方法:将膝关节骨性关节炎患者随机分为2组,分别接受玻璃酸钠和曲安奈德治疗。随访6个月,评估每组患者的膝关节疼痛评分、关节功能、活动角度。结果:曲安奈德治疗后的第1、2周疼痛缓解作用、关节功能显著优于玻璃酸钠(P<0.05)。2组患者膝关节活动度在治疗后的第1、3个月内无显著差异(P>0.05),玻璃酸钠治疗后的第6个月关节活动度显著优于曲安奈德(P<0.05)。结论:曲安奈德和玻璃酸钠均可缓解膝关节疼痛,改善功能和增加膝关节活动度。曲安奈德早期疗效优于玻璃酸钠,但持续时间较玻璃酸钠短。

Objective: To compare the efficacy of intra-articular injection of sodium hyaluronate and triamcinolone acetonide in the treatment of osteoarthritis of the knee. Methods: Patients with osteoarthritis of the knee were randomly divided into two groups. They were treated with sodium hyaluronate and triamcinolone acetonide re? spectively. All patients were followed up for 6 months to evaluate knee pain score, joint function and angle of mo? tion. Results: The pain relief effect and joint function after triamcinolone acetonide treatment at the first week and second week were significantly better than that of sodium hyaluronate(P<0.05). There was no significant difference in knee range of motion between the two groups in the first and third months after treatment(P<0.05), but at the sixth month after sodium hyaluronate treatment was significantly better than that of triamcinolone acetonide (P<0.05). Conclusion: Both triamcinolone acetonide and sodium hyaluronate can relieve knee pain, improve function and increase range of motion. The early efficacy of triamcinolone acetonide was better than that of sodium hyaluronate, but the duration was shorter than that of sodium hyaluronate.