长链非编码RNA调控乳腺癌发生发展的研究进展

Advances in Research on Long-chain Non-coding RNA Regulation of Breast Cancer Development

乳腺癌是女性最常见的疾病之一,由于本身的复杂性和异质性,使其仍然是公共卫生领域的一大难题。近几年来随着技术的发展,长链非编码RNA(lncRNA)受到了广泛的关注。大量研究表明,长链非编码RNA由于其关键的生物调控功能,在肿瘤的发生、发展中发挥着重要作用。尽管长链非编码RNA的具体分子机制尚未完全明确,但最近的研究表明,许多长链非编码RNA在多种肿瘤中表达异常,其中包括乳腺癌。本文主要对长链非编码RNA与乳腺癌的最新研究进行了综述,并进一步探索长链非编码RNA在影响乳腺癌增殖、凋亡、侵袭、转移中的分子机制。

Breast cancer is one of the most common diseases in women. Due to its complexity and heterogeneity, it is still a major problem in the field of public health. In recent years, with the development of technology, long-chain non-coding RNA (lncRNA) has received extensive attention. A large number of studies have shown that long-chain non-coding RNA plays an important role in the occurrence and development of tumors due to its key biological regulatory functions. Although the specific molecular mechanisms of long-chain non-coding RNA are not fully understood, recent studies have shown that many long-chain non-coding RNAs are abnormally expressed in a variety of tumors, including breast cancer. This article reviews the recent research on long-chain non-coding RNA and breast cancer, and further explores the molecular mechanism of long-chain non-coding RNA in affecting breast cancer proliferation, apoptosis, invasion and metastasis.