冠心病患者血清小而密低密度脂蛋白胆固醇分析

Analysis of Serum Small,Dense Low-density Lipoprotein Cholesterol in Patients with Coronary Heart Disease

目的探究冠心病患者血清小而密低密度脂蛋白胆固醇(sd-LDL)水平及其与疾病的相关性。方法选取我院2018年8月~12月收治的30例冠心病患者视为观察组,另选取同期接受体检的30例健康者视为对照组,检测两组sd-LDL水平并比较,分析sd-LDL与冠心病的相关性,行多因素Logistic分析冠心病危险因素。结果观察组sd-LDL水平高于对照组,差异有统计学意义(P<0.05);稳定性心绞痛、不稳定性心绞痛、急性心肌梗死sd-LDL水平比较,差异有统计学意义(P<0.05),其中急性心肌梗死最高,不稳定性心绞痛次之,稳定性心绞痛最低。三支病变sd-LDL水平高于单支病变和双支病变,差异有统计学意义(P<0.05);sd-LDL水平与冠心病严重程度呈正相关(r=0.645,P=0.002)。Logistic多因素回归分析显示sd-LDL是冠心病的独立危险因素。结论sd-LDL的变化与冠心病的变化密切相关,sd-LDL水平较高意味着冠心病严重程度较高,临床需采取积极地预防性措施,保持sd-LDL水平的稳定,为疾病治疗及预后改善提供参考依据。

Objective To investigate the serum levels of small, dense low-density lipoprotein cholesterol (sd-LDL) and its correlation with disease in patients with coronary heart disease. Methods Selected 30 patients with coronary heart disease admitted to our hospital from August to December 2018 and enrolled as observation group. 30 healthy subjects who underwent physical examination at the same time were selected as the control group. Checking the 2 groups of sd-LDL levels and comparing these 2 groups. The relationship between LDL and coronary heart disease was analyzed by multivariate Logistic analysis of risk factors for coronary heart disease. Results The level of sd-LDL in the observation group was higher than that in the control group,the difference was statistically significant (P<0.05). The difference of sd-LDL level between stable angina pectoris, unstable angina pectoris and acute myocardial infarction was statistically significant (P<0.05). Among them, acute myocardial infarction is the highest, unstable angina is second, and stable angina is the lowest. The levels of sd-LDL in the three lesions were higher than those in the single-vessel and double-vessel lesions,the difference was statistically significant (P<0.05). The level of sd-LDL was positively correlated with the severity of coronary heart disease (r=0.645,P=0.002). Logistic multivariate regression analysis showed that sd-LDL was an independent risk factor for coronary heart disease.Conclusion The change of sd-LDL is closely related to the change of coronary heart disease. The higher level of sd-LDL means that the severity of coronary heart disease is higher. The clinical need to take positive preventive measures to maintain the stability of sd-LDL level for disease treatment and Provide a reference for prognosis improvement.