二酰氧碘苯化合物的制备与应用研究进展

Research Progress on Preparation and Application of Bisacyloxyiodoarenes

二酰氧碘苯是最具代表性的一类三价碘化合物,在有机合成与药物化学中主要起氧化和偶联作用。本文重点介绍了利用廉价氧化剂Oxone和高级羧酸交换制备二酰氧碘苯及其衍生物的方法,以及该类化合物在氧化反应与偶联反应中的应用。并对二酰氧碘苯化合物的应用前景进行了简要展望。

Bisacyloxyiodobenzenes are the most representative types of trivalent iodine compounds, which play a very unique role as oxidants and coupling agents in organic syntheses and medicinal chemistry. This article mainly introduced two methods of the preparation of bisacyloxyiodobenzenes and derivatives by cheap oxidant oxone and advanced carboxylic acid exchange, as well as the application of trivalent iodine compounds in oxidation reactions and the coupling reactions. Finally, the application foreground of bisacyloxyiodobenzenes were proposed.