血液灌流对急性重度口服百草枯中毒预后的影响

Effect of Hemoperfusion on Prognosis of Acute Severe Oral Paraquat Poisoning

目的探讨血液灌流(HP)治疗方法对急性重度口服百草枯中毒患者的预后影响。方法收集2010年1月至2015年12月41例急性重度口服百草枯中毒患者,分析采用不同HP设备及首次HP时灌流器的使用量对急性重度口服百草枯患者预后的影响。结果41例患者的中位生存时间为3d,分别以碳肾和树脂为HP设备的患者中位生存时间均为3d,二者间生存率差异无统计学意义(χ2=0.023,P=0.88)。单因素和多因素Cox分析均显示口服百草枯剂量越大,患者死亡的风险越高(95%CI:1.00~1.02,P<0.05)。灌流器种类、首次HP治疗灌流器使用量对重度口服百草枯患者的预后均无影响(P>0.05)。结论百草枯口服剂量可影响急性重度口服百草枯患者的预后,不同种类及数量的血液灌流对患者预后无影响。

Objective To investigate the effect of hemoperfusion(HP) on the prognosis of patients with acute severe oral paraquat poisoning. Methods Forty-one patients with acute severe oral paraquat poisoning were collected from January 2010 to December 2015. The effects of different HP devices and the amount of perfusion on the prognosis of patients with acute severe oral paraquat poisoning were analyzed. Results The median survival time of 41 patients was 3 days. The median survival time of patients with HP equipped with carbon kidney and resin was 3 days. There was no significant difference between the two groups (χ2=0.023,P=0.88). Univariate and multivariate Cox analysis showed that the higher the oral dose of paraquat, the higher the risk of death(95% CI:1.00~1.02,P<0.05). The type of perfusion and the amount of perfusion used in the first HP treatment had no effect on the prognosis of patients with severe oral paraquat(P>0.05). Conclusion The higher paraquat oral dose, the higher mortality rate of the paraquat patient. The use of different HP device (carbon kidney or resin) and the hemoditoxifier number that used in the first-time HP had no significant effect on the prognosis of acute severe oral paraquat patients.